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  • Chlorpheniramine maleate is given by mouth and is used off label in cats, dogs, horses, ferrets, and birds to treat allergic conditions or as a mild sedative. Common side effects include sleepiness, although other side effects are possible.

  • Clarithromycin is given by mouth and used off label to treat certain bacterial infections in several animal species. Do not use in pets that are allergic to it or other macrolide antibiotics, in rabbits, gerbils, guinea pigs, hamsters, or horses greater than four months old.

  • Chlortetracycline (brand name Aureomycin®) is a tetracycline antibiotic used to treat certain bacterial infections in food animals, cats, dogs, birds, and some small mammals. Its use may be off label (extra label) depending on species and formulation. Do not use in guinea pigs.

  • Chocolate is toxic to cats. While rarely fatal, chocolate ingestion can result in significant illness. It contains theobromine and caffeine, which cause clinical signs such as an increase in heart rate, blood pressure, agitation, tremors, and seizures. Signs of chocolate poisoning can take several hours to develop and can last for several days.

  • Chocolate is toxic to dogs. While rarely fatal, chocolate ingestion can result in significant illness. It contains theobromine and caffeine, which cause clinical signs such as vomiting, diarrhea, increased thirst, panting or restlessness, and increased heart rate. Signs of chocolate poisoning can take several hours to develop and can last for several days.

  • Cholangitis/cholangiohepatitis syndrome (CCHS) is an inflammatory liver disease. Cholangitis is inflammation of the bile ducts. Cholangiohepatitis is inflammation of the bile ducts, gallbladder, and surrounding liver tissue. This handout outlines clinical signs, diagnosis, treatment, and prognosis.

  • Cholecalciferol is one of three main active ingredients found in rodenticides. It is commonly found as a soft bait and occasionally as a hard block or pellet. While it may seem like a safer option than anticoagulants, there is no antidote available and the amount in a single block is enough to cause a severe overdose in nearly all animals.

  • Choline (brand name Cholodin®) is a vitamin used in detoxification pathways in the liver and as a precursor to nervous system chemicals such as acetylcholine and dopamine. Supplemental choline is used in dogs and cats with seizures and/or cognitive dysfunction.

  • Chondrosarcomas arise from cartilage, which is a connective tissue primarily found where bones meet with joints, as well as at other locations in the body such as the nasal cavity, and ribs. Chondrosarcoma is a rare tumor in cats, but it can occur. Clinical signs of chondrosarcoma may vary significantly, depending on where the tumor arises. Although the mass may grow rapidly, less than 20% of feline chondrosarcoma cases metastasize to other parts of the body. Therefore, surgical removal is curative in many cases.

  • Chondrosarcomas arise from cartilage, which is a connective tissue primarily found where bones meet with joints, as well as at other locations in the body such as the nasal cavity, and ribs. Chondrosarcoma is the second-most common primary bone tumor in dogs. Canine chondrosarcoma most commonly affects the flat bones of the body, such as the ribs, skull, nasal cavity, and pelvis, although the limbs can also be affected. Aggressive surgical removal is typically recommended, although radiation therapy may also be used, depending on location of tumor. Metastasis may occur but is relatively uncommon.