Iodide (Sodium, Potassium)

What is iodide (sodium, potassium)?

Iodide (sodium, potassium) is an oral antifungal used to treat certain fungal infections (e.g., sporotrichosis) in cats and dogs.

It is used off label (extra label) in animals other than cattle. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions very carefully, as their directions may be significantly different from those on the label.

How do I give my pet iodide (sodium, potassium)?

• Iodide (sodium, potassium) comes in liquid and powder form. It may be specially compounded.
• All forms are given orally (by mouth).
• Give with food, ideally a high-fat meal.
• Measure liquid medications carefully.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

This medication should take effect within 1–2 hours, though outward effects may not be seen.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects from iodide (sodium, potassium)?

Iodide (sodium, potassium) may cause the following side effects:

• Vomiting, nausea
• Excessive tearing from the eyes

Serious adverse reactions may occur. If any of the following signs develop, stop giving iodide (sodium, potassium) and contact your veterinarian immediately:

• An allergic reaction, such as irregular breathing, rash, fever, puffiness and swelling around the face.
• Signs of iodide toxicity (severe vomiting, loss of appetite, depression, twitching, changes in fur, diarrhea, runny nose, low body temperature, and/or trouble breathing). Cats are at higher risk for iodide toxicity.

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours, though effects may be prolonged in pets with kidney and/or liver disease.

Are there any risk factors for this medication?

DO NOT USE iodide (sodium, potassium) in:

• Pets that are allergic to any component
• Pets that are pregnant or nursing
• Pets with kidney disease or hyperthyroidism
• Pets that are severely dehydrated

USE WITH CAUTION in:

• Cats, as they are more susceptible to the effects of iodide

Are there any drug interactions I should be aware of?

The following medications should be used with caution when given with iodide (sodium, potassium):

• ACE inhibitors (e.g., enalapril)
• Angiotensin receptors blockers (e.g., telmisartan)
• Antithyroid medications (e.g., methimazole)
• Potassium sparing diuretics (e.g., spironolactone)
• Potassium supplements
• Thyroid supplements (e.g., levothyroxine)

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Baseline and periodic blood work for thyroid levels and liver enzymes are required.
• At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.

How do I store iodide (sodium, potassium)?

• Store the medication at room temperature of 15°C-30°C (59°F-86°F).
• Protect from light and freezing.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.